The University of the Western Cape (UWC) and the Institute of Tropical Medicine (ITM), Antwerp, Belgium, are excited to announce the establishment of the Centre of Excellence for Pharmacovigilance in Southern Africa (CEPSA). The Centre focuses on improving the safety of medicines and vaccines. Supported by a recent grant from the European Commission DG International Partnerships (INTPA, in close collaboration with DG Research (RDT), this initiative marks a big step forward in making medicines safer and more accessible across the region.